Thursday, June 27, 2013

Discovery Communications working on a HBO Go-esque streaming service

Discovery Communications working on a HBO Goesque streaming service

Discovery Channel, DMAX, 3NET (with Sony and IMAX) and Revision 3 owner Discovery Communications is pondering an HBO Go-style streaming service. In an interview with Reuters, company boss John Hendricks said that shows that are between three and 18 months old can still make money before they're launched on Netflix. His plan is to let subscribers access that programming online for a small additional monthly fee, which, according to Hendricks' autobiography, is between $6 and $8 a month. The boss also said that the company is developing the infrastructure for the platform, but that we won't see such a service arrive for anything up to five years.

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Source: Reuters

Source: http://www.engadget.com/2013/06/26/discovery-online-streaming-service/?utm_medium=feed&utm_source=Feed_Classic&utm_campaign=Engadget

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Wednesday, June 26, 2013

Type 1 diabetes vaccine shows promise in early study: researchers

By Julie Steenhuysen

CHICAGO (Reuters) - An early stage study suggests an experimental vaccine may be able to tame bits of the immune system that go haywire in people with type 1 diabetes, offering hope for a new way to delay or prevent the autoimmune disease, researchers said on Wednesday.

For more than four decades, scientists have tried different ways of manipulating the immune system to stop the destruction of insulin-producing cells that is responsible for type 1 diabetes. The disease affects as many as 3 million Americans.

Some prior attempts suppressed desirable parts of the immune system, leaving individuals vulnerable to infections and cancer. Several teams are now attempting more targeted approaches in an effort to delay or reverse type 1 diabetes.

Those with this form of diabetes currently must monitor their blood sugar and take insulin several times a day, but the treatment is risky - it can cause coma or death at any time and can lead to heart disease, nerve damage, blindness and kidney failure over time.

"What one really wants to do is tame or regulate the specific aspects of the immune system that have gone awry and leave the rest of the immune system intact," said Dr. Richard Insel, chief scientific officer of JDRF, formerly known as the Juvenile Diabetes Research Foundation.

In the latest effort, published on Wednesday in the journal Science Translational Medicine, teams from Leiden University Medical Center in the Netherlands and Stanford University in California tested a vaccine genetically engineered to shut down only the immune system cells causing harm, while leaving the rest of the immune system intact.

"The idea here is to turn off just the rogue immune cells that are attacking the pancreas and killing the beta cells that secrete insulin," said Stanford Professor Dr. Lawrence Steinman, one of the study's senior authors and co-founder of a company called Tolerion recently formed to commercialize the vaccine.

The study, done in 80 people diagnosed with type 1 diabetes who were receiving insulin injections, was designed to test the safety of the vaccine known as TOL-3021. The so-called DNA vaccine is made up of a small round piece of DNA called a plasmid that is genetically engineered to tamp down the immune response to insulin and preserve insulin-producing beta cells.

The vaccine targets a precursor protein in the blood called proinsulin. "It's a complicated series of snips and cuts in the DNA that take away the capability to stimulate the immune system," Steinman said.

"This effectively triggers an off-switch," he said.

After 12 weeks of shots given once a week, patients who got the vaccine showed signs that they helped preserve some of the remaining insulin-producing beta cells in the pancreas without causing serious side effects.

The vaccine also reduced the number of killer immune cells known as T cells. And patients who got the active vaccine had higher levels of C-peptides - a remnant of insulin production in the blood that suggests the presence of more working beta cells.

Steinman admits the vaccine is far from commercial use, but the study is promising enough to do a bigger study.

"So far, it looks like it is doing what we want," he said.

Insel said it was too early to say much about the vaccine's promise. "It looks like it has some potential, but very small numbers," he said.

"This was done initially as a safety and dose-finding study. They were surprised to get these kinds of results," he said.

Stanford has licensed rights to the vaccine to California-based Tolerion, which is designing a longer study in as many as 200 patients to test whether the vaccine can slow or stop progression of the disease in younger patients, before too much damage has been done.

Insel said the work is one of several efforts aimed at developing a vaccine for type 1 diabetes. Such a vaccine could help people with active type 1 diabetes preserve residual beta cells, giving them better control of their disease and potentially getting them off insulin.

Ultimately, the hope is to develop an effective vaccine that could be given to individuals who are genetically predisposed to develop the condition, he said.

The World Health Organization estimates that about 10 percent of the 350 million people in the world with diabetes have the type 1 variety - most have type 2, which is associated with obesity and lack of exercise.

(Reporting by Julie Steenhuysen; Editing by Paul Simao)

Source: http://news.yahoo.com/type-1-diabetes-vaccine-shows-promise-early-study-180404550.html

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Tuesday, June 25, 2013

?Badass Teachers? Fights for Public Education

A group calling themselves the Badass Teacher Association (BAT) launched a campaign on Monday against America's federal education policies.

The 15,000-plus strong Internet group spent Monday making hundreds of calls to the White House switchboard to tell President Barack Obama to replace Arne Duncan as Secretary of Education. Instead, the teachers want a lifetime educator who better understands and empathizes with teachers and parents.?

The White House call was the first action since the group started about a week ago with an initial 100 members on Facebook.

The group is part of an ongoing revolution in education in which teachers, parents, and students are exasperated and exhausted by the Obama administration?s Race to the Top proposals and the testing they require, the?Common Core State Standards, and school closings.


?I think that many teachers hoped that if Barack Obama was re-elected, he would ease up on the testing, and the school closings, and the test-driven teacher evaluations,? Mark Naison, a professor of African-American studies and history at Fordham University and a cofounder of the Badass Teachers Association, told TakePart. Instead, he doubled down on all of those, ?leaving teachers with no other option than to speak out in the most forceful way possible, say, ?enough is enough,? and demand a seat at the table in shaping education policy, which they emphatically do not have now.?

There?s long been a push for Obama to replace Duncan, a longtime friend of the president?s from their days in Chicago. Obama picked him as his Education Secretary soon after he was elected in 2008. From 2001 until then, he worked as chief executive officer of the Chicago Public Schools.

Duncan has plenty of foes from his Chicago days, particularly those who disapproved of his successful efforts to shutter underperforming schools and replace them with charter schools.

?I want BAT to show everyone that we are not going away quietly, that we see the true agenda and it isn't about better education,? Marla Kilfoyle, a teacher in California, said. ?It is about profit and privatizing our public school system. I hope that BAT exposes that the school closings we are seeing in our inner city neighborhoods are not about helping kids but about business and money. I would like to see BAT expose that to the public and dismantle it so that we can start doing some real work that is genuine.?


Priscilla Sanstead, cofounder of the group and an activist parent, said she helped to get the BAT group started because she likes to connect people and ask questions that ?a lot of people won't just go ahead and say out loud.?

Sanstead said that she wants big changes in education. She specifically wants standardized testing to be reigned way back, portfolios to become an accepted way to assess students, and for teachers to get a voice in setting education policy, she said. ?I want smaller class sizes, too, and the way to do that is to spend money hiring more teachers.?

Bonnie Cunard, a Florida teacher and parent, is a member of the group. She says that although she can see education reform from both sides, things still need to change.

?Mostly, I see depleted public schools and our public funds channeled to testing corporations and corporate, for-profit charter schools,? Cunard said. ?I see high-stakes tests strangling the education of children everywhere, including my own children.?

I'm very tired of teachers not being allowed to be a part of the decision-making process that affects our everyday lives and the lives of our students.

She says that she hopes this group will awaken teachers across the nation ?to the fact that many of us are fighting these same issues?that we are not alone...I also hope to take proactive steps to change policies regarding high-stakes testing, privatization, and depleted funding of public schools.?

Michael Pe?a, a public school teacher in Washington who led the charge to call the White House, says he hopes the group accomplishes three things: reduce or eliminate the use of high-stakes testing, increase teacher autonomy in the classroom, and include teacher's voices in legislative decision-making processes.

?I'm tired of being pointed at as the problem in education by people who don't understand the complexity of the public education system and how decisions are made by elected and unelected officials,? Pe?a told TakePart. ?I'm very tired of teachers not being allowed to be a part of the decision-making process that affects our everyday lives and the lives of our students.?

Many teachers are demanding that they have more control over their profession.

?We are professionals? Denisha Jones, a professor at Howard University and a teacher educator, told TakePart. ?We are educated. We deserve to make decisions regarding our craft. I hope that through this group, teachers can come together, organize, and save the profession from the corporate takeover of public education.?


Related stories on TakePart:

Source: http://news.yahoo.com/badass-teachers-fights-public-education-233400713.html

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Windows 8.1 Start button makes cameo in Server 2012 R2 Preview

Windows 81 Start button makes cameo in Server 2012 R2 Preview

It's back! Yes, what you're looking at above is the Start button (plus matching options) that's been rumored to return with Windows 8.1 (formerly "Blue"). Yesterday .NET developer Robert McLaws tweeted a series of screenshots of Windows Server 2012 R2 Preview (build 9431) which show the new Start button and a revised "Taskbar and Navigation properties" dialog -- among other things. Microsoft faced massive criticism last year after shipping Windows 8 without the Start button -- prompting third parties to create replacements (like Start8 and Classic Shell) -- so this is a welcome change. Stay tuned for Build 2013 (the company's developer conference) which starts Wednesday in San Francisco -- we're likely to find out more about Windows 8.1 and the Start button in short order.

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Via: WinBeta

Source: Robert McLaws (Twitter)

Source: http://www.engadget.com/2013/06/25/windows-8-1-start-button-makes-cameo-in-server-2012-r2-preview/?utm_medium=feed&utm_source=Feed_Classic&utm_campaign=Engadget

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From tiny to massive: Mammal size evolution explained

June 25, 2013 ? Scientists have added another piece to the evolutionary puzzle to explain why certain mammal families evolved to be very large, while others remained tiny.

In research published in Proceedings of the Royal Society B, an international group of scientists including Monash University's Dr Alistair Evans proposed a new theory explaining the diversity of mammal sizes -- from the Etruscan shrew which weighs around two grams, to the blue whale which clocks in at almost 200 tonnes. Surprisingly, baby weight relative to adult body mass is key.

Dr Evans, of the Monash School of Biological Sciences, said size impacts on all aspects of an animal's physiology and anatomy, and the roles it can play in ecosystems.

"Size is fundamental to your life and your body -- how fast your heart beats, how much food you need to eat, and how you move," Dr Evans said.

Following the extinction of the dinosaurs, mammals flourished and their size increased dramatically. The study examined the maximum size of groups including whales, elephants, primates and rodents over this period to examine the constraints on size.

The researchers found that species that matured more quickly and produced a larger mass of young each year relative to body weight were able to evolve to a larger maximum size. Further, they are likely to reach that size in fewer generations.

This high rate of biological production is vital, regardless of whether many small young or just one large offspring are born in a year.

Dr Evans said whales were an excellent example of the theory.

"The blue whale is the largest animal to have evolved, even larger than dinosaurs, and it reached this size at the fastest rates we recorded. Key to this success is that they produce large young that mature quickly, reaching around 30 metres in eight to 10 years," Dr Evans said.

Lead author of the study, Dr Jordan Okie from Arizona State University, said primates were at the opposite end of the spectrum.

"Primates have a low production rate and have evolved very slowly. They have never got bigger than about 500 kilograms," Dr Okie said.

The study also linked maximum size to mortality rate. Because larger animals tend to breed less frequently than smaller animals, if the mortality rate doubles, the maximum size is predicted to be 16 times smaller.

"This is a really surprising finding," said Dr Evans.

"It points to why many of the large animals went extinct after the last Ice Age, as changing climates probably increase mortality rates. Large animals are also at high risk of extinction in modern environments because it takes a long time for their population to rebound from disasters."

In the future, this work will be extended to help explain how extinction risk may be reduced in the face of climate change.

Source: http://feeds.sciencedaily.com/~r/sciencedaily/top_news/top_environment/~3/WVYra1sPi-A/130625092012.htm

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Friday, June 21, 2013

Life Unexpected: Our First Baby Shower...

It's been three weeks since we passed court and it feels like eternity. ?Every day that passes is one more day that we are away from Biruk, and we are not big fans of that! ?We are praying that we get submitted to embassy, pass, and travel as soon as possible. ?In the meantime, we are "prepping" to be parents, and basking in all of the "firsts" of pre-parenthood. ?I realized tonight that not only has it been three weeks since court, but it has also been almost three weeks since I last blogged. ?I am behind and so much has happened.

For starters, my family threw us the baby shower of the century and I haven't even had time to blog about it. Several months back, my mom and sisters came to me attempting to find a date that would work for all of us to have a baby shower. ?After a lot of debating, we chose a date, and then several weeks later, changed the date in fear that it would be too close to traveling for our first trip. ?Little did we know that our first trip would come a lot sooner than we thought. ?We came home from Ethiopia on a Thursday and the baby shower of the century was two days later on a Saturday. ?While it was a crazy busy time, it couldn't have been more perfect timing to celebrate the news that we were officially Biruk's parents. ?That makes for some serious celebration.

If you know anything about my family, than you know no one does anything halfheartedly. ?When my mom and sisters started making plans for the shower, I knew that it would not be a simple task. ?For weeks leading up, whenever I talked with them on the phone, they reminded me that it was going to be awesome. ?They had every detail planned out, they had invited friends and family from out of town, and they wanted to make sure it was amazing.

Nate and I had decided to just go home to my parent's house as soon as we got in from Ethiopia. ?Since my sister was in town, Nate's family was coming, and we had friends coming, we thought we would spend a few days home. ?Friday morning, I woke up and was completely jet lagged and groggy. ?I headed downstairs and found some coffee my Dad had made and then he informed me that he needed me to come to the airport that night and translate (in Spanish) for a pastor coming to visit from Cuba who didn't speak any English. ?At that point, I was so tired, I was lucky I could speak English. ?Regardless, I agreed, and that night my Dad and I set out to the airport.

We arrived at BWI and began searching for this Cuban pastor. ?I was frantically trying to remember every Spanish phrase I could think of, while asking my Dad over and over again a series of questions as we waited..."What does he look like? ?Are you sure he doesn't speak any English? ?What gate is he coming from? ?Are you sure he doesn't speak any English?" ?Finally, after about 30 minutes of waiting, my Dad blurted out, "It's Amy Hanes!" ?I was like, "What's Amy Hanes?" ?He said, "Amy...she is coming to surprise you for your shower but I have no idea where she is. ?Do you have your her number in your cell?" ?Amy is one of my friends, who is a missionary in Honduras. ?She had come to surprise me for my shower. ?I turned around and saw her right away and then started freaking out. ?The weekend was already off to an amazing start.

Saturday morning, we headed to the church and I was completely blown away by what I saw. ?My mom and sisters had truly out done themselves. ?There were pennants that were hanging with maps of Ethiopia, little kid party favors with pencils with mini flags on them, several of Biruk's little shirts hanging up, cupcakes that had cake pops in the center of them, food that was amazing every where, the cutest mason jars with Biruk's picture attached and yummy chocolate covered oreos and pretzels inside (thanks to my sister, Heather), and pictures of our trip pinned all over.

Side ?note on the pictures...so my Dad went to CVS to get 5 sets of about 20 pictures of Biruk developed. ?The CVS girl came over to him and said, "This is a beautiful baby!" ?My Dad tried to reply, "That's my new grandson," but in Dad fashion, broke down in tears overwhelmed by the goodness of the whole thing. ?The girl put her arm around him and said, "Sir, are you going to be ok?" ?Oh my...I would have paid to see that.

Mom had placed plain burp cloths everywhere along with fabric markers. ?She asked everyone to decorate one (which by the way, there were over 65 people there to support us!). ?She also asked everyone to write Biruk blessings, which totally blew us away. ?I can't wait until he is old enough for us to read them some day. ?My sister Kristen gave us this awesome wall hanging of Africa with the lyrics to a powerful Steven Curtis Chapman song. ?It's already hanging in Biruk's room ?My sister Heather had this beautiful necklace made that had a bunch of charms that represented our journey. ?I have been wearing it like crazy! ?Nate's mom and sister even made it down...driving 6 hours to stay for a few hours. ?It meant the world to us.

I had always imagined what it would be like to have a baby shower someday, but I could have never dreamed up the amount of encouragement and love we felt that day. ?It wasn't about gifts that we got (although, we got more than enough gifts...people were incredibly generous). ?It wasn't about the decorations (although I am pretty sure that my mom and sisters could easily go into the business of baby showers...it was that amazing). ?It wasn't even about us. ?It was totally about God's grace and faithfulness in a story that we could have never written or imagined if we tried. ?It was about a community of friends and family members who have been praying like crazy for a child they have never even met. ?It was about the celebration of a baby whose name not only means "blessed," but whose whole story has been a blessing in ways we could have never dreamed of. ?It was about a God who never stops loving us and a God who is constantly weaving the threads of our lives to make something beautiful. ?That is what blows us away. ?That is what we are grateful for. ?That is what makes the journey incredible. ?Thanks be to God.

Source: http://nateandandrealifeunexpected.blogspot.com/2013/06/our-first-baby-shower.html

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